产品名称
GLIS2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84662
Human Swissprot No.
Q9BZE0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZE0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/83396
Mouse Swissprot No.
Q8VDL9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VDL9
免疫原
Synthesized peptide derived from human GLIS2 AA range: 442-492
特异性
This antibody detects endogenous levels of GLIS2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010],
组织表达
Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
细胞定位
Nucleus speckle . Cytoplasm .
功能
disease:Defects in GLIS2 are the cause of nephronophthisis type 7 (NPHP7) [MIM:611498]. NPHP7 is an autosomal recessive disorder resulting in end-stage renal disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.,domain:The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding.,function:Can act either as a transcription repressor or as a transcription activator, depending on the cell context. Represses the transcriptional activation mediated by CTNNB1 in the Wnt pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.,PTM:C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Interacts with CTBP1 and HDAC3. Interacts with CTNNB1 (By similarity). Interacts with CTNND1.,tissue specificity:Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
