产品名称
IRTKS Rabbit Polyclonal Antibody
别名
BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
蛋白名称
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55971
Human Swissprot No.
Q9UHR4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UHR4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66898
Mouse Swissprot No.
Q9DBJ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBJ3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304282
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q3KR97
免疫原
The antiserum was produced against synthesized peptide derived from human BAIAP2L1. AA range:111-160
特异性
IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo
组织表达
Adrenal gland,Epithelium,Lung,Placenta,
细胞定位
Cytoplasm, cytoskeleton . Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
功能
domain:The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation.,function:May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles.,PTM:Phosphorylated on tyrosine in response to insulin.,similarity:Contains 1 IMD (IRSp53/MIM homology) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with RAC1. Binds to F-actin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
