产品名称
IRAK-2 Rabbit Polyclonal Antibody
别名
IRAK2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2
蛋白名称
Interleukin-1 receptor-associated kinase-like 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3656
Human Swissprot No.
O43187
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43187/entry
Mouse Swissprot No.
Q8CFA1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CFA1
免疫原
Synthesized peptide derived from the Internal region of human IRAK-2.
特异性
IRAK-2 Polyclonal Antibody detects endogenous levels of IRAK-2 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008],
组织表达
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
细胞定位
nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,
信号通路
Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Neurotrophin;
功能
caution:Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.,tissue specificity:Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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