产品名称
IPP-2 Rabbit Polyclonal Antibody
别名
PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2
蛋白名称
Protein phosphatase inhibitor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5504
Human Swissprot No.
P41236
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P41236/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66849
Mouse Swissprot No.
Q9DCL8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCL8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=192361
Rat Swissprot Link
http://www.uniprot.org/uniprot/P50411
免疫原
The antiserum was produced against synthesized peptide derived from human PPP1R2. AA range:86-135
特异性
IPP-2 Polyclonal Antibody detects endogenous levels of IPP-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
组织表达
Epithelium,Heart,Platelet,Skin,Testis,
细胞定位
protein phosphatase type 1 complex,
功能
function:Inhibitor of protein-phosphatase 1.,PTM:Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.,similarity:Belongs to the protein phosphatase inhibitor 2 family.,subunit:Heterodimer with PP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
