产品名称
IP Receptor Rabbit Polyclonal Antibody
别名
PTGIR; PRIPR; Prostacyclin receptor; Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
蛋白名称
Prostacyclin receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5739
Human Swissprot No.
P43119
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P43119/entry
Mouse Swissprot No.
P43252
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P43252
免疫原
The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247
特异性
IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],
组织表达
Lung,Pancreas,Placenta,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;
功能
function:Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
