产品名称
Involucrin Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3713
Human Swissprot No.
P07476
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07476/entry
Mouse Swissprot No.
P48997
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48997
免疫原
The antiserum was produced against synthesized peptide derived from human Involucrin. AA range:536-585
特异性
Involucrin Polyclonal Antibody detects endogenous levels of Involucrin protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
involucrin(IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008],
组织表达
Keratinocytes of epidermis and other stratified squamous epithelia.
细胞定位
Cytoplasm. Constituent of the scaffolding of the cornified envelope.
功能
function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.,PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.,similarity:Belongs to the involucrin family.,subcellular location:Constituent of the scaffolding of the cornified envelope.,subunit:Directly or indirectly cross-linked to cornifelin (CNFN).,tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
