产品名称
Cleaved-MMP-23 (Y79) Rabbit Polyclonal Antibody
别名
MMP23A; MMP21; MMP23B; MMP21; MMP22; Matrix metalloproteinase-23; MMP-23; Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22
蛋白名称
Matrix metalloproteinase-23
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8510
Human Swissprot No.
O75900
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75900/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26561
Mouse Swissprot No.
O88676
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88676
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94339
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88272
免疫原
The antiserum was produced against synthesized peptide derived from human MMP23. AA range:60-109
特异性
Cleaved-MMP-23 (Y79) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-23 protein resulting from cleavage adjacent to Y79.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in ovary, testis and prostate.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . A secreted form produced by proteolytic cleavage may also exist. .
功能
cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by TIMP2.,function:Protease.,PTM:N-glycosylated.,PTM:Proteolytic cleavage might yield an active form.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subcellular location:A secreted form produced by proteolytic cleavage seems also to exist.,tissue specificity:Predominantly expressed in ovary, testis and prostate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
