产品名称
Integrin β5 Rabbit Polyclonal Antibody
别名
ITGB5; Integrin beta-5
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3693
Human Swissprot No.
P18084
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18084/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16419
Mouse Swissprot No.
O70309
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70309
免疫原
The antiserum was produced against synthesized peptide derived from human Integrin beta5. AA range:721-770
特异性
Integrin β5 Polyclonal Antibody detects endogenous levels of Integrin β5 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 PSI domain.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.,
组织表达
Brain,Kidney,Thymic epithelium,
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Focal adhesion;ECM-receptor interaction;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
function:Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 PSI domain.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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