产品名称
InsP 3-kinase C Rabbit Polyclonal Antibody
别名
ITPKC; IP3KC; Inositol-trisphosphate 3-kinase C; Inositol 1; 4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C
蛋白名称
Inositol-trisphosphate 3-kinase C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80271
Human Swissprot No.
Q96DU7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96DU7/entry
Mouse Swissprot No.
Q7TS72
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TS72
免疫原
The antiserum was produced against synthesized peptide derived from human IP3KC. AA range:221-270
特异性
InsP 3-kinase C Polyclonal Antibody detects endogenous levels of InsP 3-kinase C protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009],
组织表达
Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
细胞定位
Nucleus . Cytoplasm . Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. .
功能
catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,disease:Genetic variations in ITPKC influence susceptibility to Kawasaki disease [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.,function:Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.,similarity:Belongs to the inositol phosphokinase (IPK) family.,subcellular location:Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.,tissue specificity:Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
