产品名称
InsP 3-kinase B Rabbit Polyclonal Antibody
别名
ITPKB; Inositol-trisphosphate 3-kinase B; Inositol 1; 4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B
蛋白名称
Inositol-trisphosphate 3-kinase B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3707
Human Swissprot No.
P27987
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P27987/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54260
Rat Swissprot Link
http://www.uniprot.org/uniprot/P42335
免疫原
Synthesized peptide derived from InsP 3-kinase B . at AA range: 130-210
特异性
InsP 3-kinase B Polyclonal Antibody detects endogenous levels of InsP 3-kinase B protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cerebellum,Colon,Hippocampus,Platelet,Skin,
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Endoplasmic reticulum .
信号通路
Inositol phosphate metabolism;Calcium;Phosphatidylinositol signaling system;
功能
catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.,similarity:Belongs to the inositol phosphokinase (IPK) family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
