产品名称
INSL4 Rabbit Polyclonal Antibody
别名
INSL4; Early placenta insulin-like peptide; EPIL; Insulin-like peptide 4; Placentin
蛋白名称
Early placenta insulin-like peptide
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3641
Human Swissprot No.
Q14641
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14641/entry
免疫原
The antiserum was produced against synthesized peptide derived from human INSL4. AA range:41-90
特异性
INSL4 Polyclonal Antibody detects endogenous levels of INSL4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008],
组织表达
Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.
功能
developmental stage:Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments.,function:May play an important role in trophoblast development and in the regulation of bone formation.,similarity:Belongs to the insulin family.,tissue specificity:Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
