产品名称
ILKAP Rabbit Polyclonal Antibody
别名
ILKAP; Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILKAP
蛋白名称
Integrin-linked kinase-associated serine/threonine phosphatase 2C
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80895
Human Swissprot No.
Q9H0C8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H0C8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67444
Mouse Swissprot No.
Q8R0F6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R0F6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64538
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1Z6
免疫原
The antiserum was produced against synthesized peptide derived from human ILKAP. AA range:41-90
特异性
ILKAP Polyclonal Antibody detects endogenous levels of ILKAP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.,induction:Inhibited rather than stimulated by Magnesium.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.,tissue specificity:Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
