产品名称
IL-5 Rabbit Polyclonal Antibody
别名
IL5; Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3567
Human Swissprot No.
P05113
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P05113/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16191
Mouse Swissprot No.
P04401
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P04401
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q08125
免疫原
The antiserum was produced against synthesized peptide derived from human IL-5. AA range:43-92
特异性
IL-5 Polyclonal Antibody detects endogenous levels of IL-5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013],
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;Hematopoietic cell lineage;T_Cell_Receptor;Fc epsilon RI;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Allograft rejection;
功能
function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.,online information:Interleukin-5 entry,similarity:Belongs to the IL-5 family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
