产品名称
IL-4I1 Rabbit Polyclonal Antibody
别名
IL4I1; FIG1; L-amino-acid oxidase; LAAO; LAO; Interleukin-4-induced protein 1; IL4-induced protein 1; Protein Fig-1; hFIG1
蛋白名称
L-amino-acid oxidase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=259307
Human Swissprot No.
Q96RQ9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96RQ9/entry
Mouse Swissprot No.
O09046
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O09046
免疫原
Synthesized peptide derived from the N-terminal region of human IL-4I1.
特异性
IL-4I1 Polyclonal Antibody detects endogenous levels of IL-4I1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
组织表达
Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310).
细胞定位
Secreted . Lysosome . Cytoplasmic vesicle, secretory vesicle, acrosome . Secreted at the immunological synapse. .
信号通路
Alanine; aspartate and glutamate metabolism;Cysteine and methionine metabolism;Valine; leucine and isoleucine degradation;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Phenylalanine; tyrosine and tryptophan biosynthesis;
功能
catalytic activity:An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).,cofactor:FAD.,function:Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation.,induction:By interleukin-4.,similarity:Belongs to the flavin monoamine oxidase family. FIG1 subfamily.,tissue specificity:Primarily found in immune tissues (isoform 1).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
