产品名称
IL-4 Rabbit Polyclonal Antibody
别名
IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3565
Human Swissprot No.
P05112
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P05112/entry
Mouse Swissprot No.
P07750
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07750
免疫原
Synthesized peptide derived from the C-terminal region of human IL-4.
特异性
IL-4 Polyclonal Antibody detects endogenous levels of IL-4 protein.
稀释度
WB 1:500-2000;Flow Cyt 1:50-200;ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Blood,PCR rescued clones,
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;Hematopoietic cell lineage;T_Cell_Receptor;Fc epsilon RI;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Allograft rejection;
功能
disease:Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.,similarity:Belongs to the IL-4/IL-13 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
