产品名称
IL-2Rβ Rabbit Polyclonal Antibody
别名
IL2RB; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; p75; CD antigen CD122
蛋白名称
Interleukin-2 receptor subunit beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3560
Human Swissprot No.
P14784
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P14784/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16185
Mouse Swissprot No.
P16297
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P16297
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25746
Rat Swissprot Link
http://www.uniprot.org/uniprot/P26896
免疫原
The antiserum was produced against synthesized peptide derived from human IL-2R beta. AA range:331-380
特异性
IL-2Rβ Polyclonal Antibody detects endogenous levels of IL-2Rβ protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an up
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;Endocytosis;Jak_STAT;
功能
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 1 fibronectin type-III domain.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
