产品名称
IL-20Rα Rabbit Polyclonal Antibody
别名
IL20RA; Interleukin-20 receptor subunit alpha; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; Cytokine receptor class-II member 8; Cytokine receptor family 2 member 8; CRF2-8; IL-20R1; ZcytoR7
蛋白名称
Interleukin-20 receptor subunit alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53832
Human Swissprot No.
Q9UHF4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UHF4/entry
Mouse Swissprot No.
Q6PHB0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6PHB0
免疫原
The antiserum was produced against synthesized peptide derived from human IL-20Ralpha. AA range:173-222
特异性
IL-20Rα Polyclonal Antibody detects endogenous levels of IL-20Rα protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
细胞定位
Membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
function:The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer with IL20RB and heterodimer with IL10RB.,tissue specificity:Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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