产品名称
IL-20 Rabbit Polyclonal Antibody
别名
IL20; ZCYTO10; Interleukin-20; IL-20; Cytokine Zcyto10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50604
Human Swissprot No.
Q9NYY1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NYY1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58181
Mouse Swissprot No.
Q9JKV9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JKV9
免疫原
The antiserum was produced against synthesized peptide derived from human IL-20. AA range:12-61
特异性
IL-20 Polyclonal Antibody detects endogenous levels of IL-20 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008],
组织表达
Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
function:Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.,similarity:Belongs to the IL-10 family.,tissue specificity:Expressed at very low levels in skin, trachea, and other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
