产品名称
IL-2 Rabbit Polyclonal Antibody
别名
IL2; Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3558
Human Swissprot No.
P60568
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P60568/entry
Mouse Swissprot No.
P04351
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P04351
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116562
Rat Swissprot Link
http://www.uniprot.org/uniprot/P17108
免疫原
The antiserum was produced against synthesized peptide derived from human IL-2. AA range:16-65
特异性
IL-2 Polyclonal Antibody detects endogenous levels of IL-2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],
组织表达
Blood,PCR rescued clones,Placenta,Spleen,
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;T_Cell_Receptor;Intestinal immune network for IgA production;Type I diabetes mellitus;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;
功能
disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
