产品名称
IL-17Rα Rabbit Polyclonal Antibody
别名
IL17RA; IL17R; Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD antigen CD217
蛋白名称
Interleukin-17 receptor A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23765
Human Swissprot No.
Q96F46
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96F46/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16172
Mouse Swissprot No.
Q60943
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60943
免疫原
The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190
特异性
IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
