BD-PT2311-IL-12A Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

IL-12A Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT2311

产品名称

IL-12A Rabbit Polyclonal Antibody

别名

IL12A; NKSF1; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1

类别

常规抗体

基因名称

IL12A

蛋白名称

Interleukin-12 subunit alpha

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

3592

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3592

Human Swissprot No.

P29459

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P29459/entry

Mouse Gene ID

16159

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16159

Mouse Swissprot No.

P43431

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P43431

Rat Gene ID

84405

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84405

Rat Swissprot No.

Q9R103

Rat Swissprot Link

http://www.uniprot.org/uniprot/Q9R103

免疫原

The antiserum was produced against synthesized peptide derived from human IL-12A. AA range:16-65

特异性

IL-12A Polyclonal Antibody detects endogenous levels of IL-12A protein.

稀释度

WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200

预测分子量

25kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008],

组织表达

Brain,Placenta,

细胞定位

Secreted .

信号通路

Cytokine-cytokine receptor interaction;Toll_Like;RIG-I-like receptor;Jak_STAT;Type I diabetes mellitus;Allograft rejection;

功能

function:Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.,online information:Interleukin-12 entry,similarity:Belongs to the IL-6 superfamily.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of IL-12A antibody in paraffin-embedded human brain tissue.

Western blot analysis of lysate from HeLa cells, using IL-12A antibody.

Western Blot analysis of HeLa cells using IL-12A Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human Amygdala. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.