产品名称
Ikaros 3 Rabbit Polyclonal Antibody
别名
IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3
蛋白名称
Zinc finger protein Aiolos
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22806
Human Swissprot No.
Q9UKT9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UKT9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22780
Mouse Swissprot No.
O08900
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08900
免疫原
The antiserum was produced against synthesized peptide derived from human IKZF3. AA range:361-410
特异性
Ikaros 3 Polyclonal Antibody detects endogenous levels of Ikaros 3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012],
组织表达
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
细胞定位
Nucleus . Cytoplasm .; [Isoform 1]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 11]: Nucleus .; [Isoform 14]: Nucleus . Cytoplasm .; [Isoform 12]: Cytoplasm .
功能
function:Transcription factor that plays an important role in the regulation of lymphocyte differentiation.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
