产品名称
Cleaved-MMP-10 (F99) Rabbit Polyclonal Antibody
别名
MMP10; STMY2; Stromelysin-2; SL-2; Matrix metalloproteinase-10; MMP-10; Transin-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4319
Human Swissprot No.
P09238
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09238/entry
Mouse Swissprot No.
O55123
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55123
免疫原
The antiserum was produced against synthesized peptide derived from human MMP10. AA range:80-129
特异性
Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016],
组织表达
Coronary artery,Ovary,
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
catalytic activity:Similar to stromelysin 1, but action on collagen types III, IV and V is weak.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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