产品名称
IGSF4B Rabbit Polyclonal Antibody
别名
CADM3; IGSF4B; NECL1; SYNCAM3; TSLL1; Cell adhesion molecule 3; Brain immunoglobulin receptor; Immunoglobulin superfamily member 4B; IgSF4B; Nectin-like protein 1; NECL-1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like protein 1; TS
蛋白名称
Cell adhesion molecule 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57863
Human Swissprot No.
Q8N126
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N126/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94332
Mouse Swissprot No.
Q99N28
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99N28
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360882
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q1WIM3
免疫原
The antiserum was produced against synthesized peptide derived from human CADM3. AA range:141-190
特异性
IGSF4B Polyclonal Antibody detects endogenous levels of IGSF4B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
cell adhesion molecule 3(CADM3) Homo sapiens IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008],
组织表达
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell junction .
信号通路
Cell adhesion molecules (CAMs);
功能
domain:The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.,function:Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.,induction:Markedly in glioma cell lines and prostate cancer cell lines.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localized at the cell-cell attached sites of the plasma membrane.,subunit:Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.,tissue specificity:Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
