产品名称
IFN-γ Rabbit Polyclonal Antibody
别名
IFNG; Interferon gamma; IFN-gamma; Immune interferon
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3458
Human Swissprot No.
P01579
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01579/entry
Mouse Swissprot No.
P01580
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P01580
免疫原
The antiserum was produced against synthesized peptide derived from human IFN-gamma. AA range:20-69
特异性
IFN-γ Polyclonal Antibody detects endogenous levels of IFN-γ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015],
组织表达
Released primarily from activated T lymphocytes.
信号通路
Proteasome;Cytokine-cytokine receptor interaction;Regulation of autophagy;TGF-beta;Jak_STAT;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Type I diabetes mellitus;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;
功能
disease:In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.,function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.,online information:Interferon gamma entry,pharmaceutical:Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).,PTM:Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.,similarity:Belongs to the type II (or gamma) interferon family.,subunit:Homodimer.,tissue specificity:Released primarily from activated T lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
