产品名称
ICAM-2 Rabbit Polyclonal Antibody
别名
ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
蛋白名称
Intercellular adhesion molecule 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3384
Human Swissprot No.
P13598
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13598/entry
Mouse Swissprot No.
P35330
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35330
免疫原
The antiserum was produced against synthesized peptide derived from human ICAM2. AA range:151-200
特异性
ICAM-2 Polyclonal Antibody detects endogenous levels of ICAM-2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Aorta endothelial cell,Blood,Brain,Endothelial cell,Plasma,Spleen,
细胞定位
Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Co-localizes with RDX, EZR and MSN in microvilli. .
信号通路
Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;
功能
function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.,online information:ICAM-2,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
