产品名称
HSP70 Rabbit Polyclonal Antibody
别名
HSPA1L; Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 1-Hom; HSP70-Hom; HSPA1A; HSPA1; HSPA1B; Heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2
蛋白名称
Heat shock 70 kDa protein 1-like/Heat shock 70 kDa protein 1A/1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
3305/3303/3304
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3305
Human Swissprot No.
P34931/P08107
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P34931/entry
Mouse Gene ID
15482/193740
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15482
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24963
Rat Swissprot No.
P55063/Q07439
Rat Swissprot Link
http://www.uniprot.org/uniprot/P55063
免疫原
The antiserum was produced against synthesized peptide derived from human HSPA1L. AA range:221-270
特异性
HSP70 Polyclonal Antibody detects endogenous levels of HSP70 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008],
组织表达
Expressed in spermatids.
细胞定位
zona pellucida receptor complex,nucleoplasm,mitochondrial matrix,cytosol,COP9 signalosome,cell body,blood microparticle,
信号通路
Spliceosome;MAPK_ERK_Growth;MAPK_G_Protein;Endocytosis;Antigen processing and presentation;
功能
function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.,induction:Not induced by heat shock.,similarity:Belongs to the heat shock protein 70 family.,tissue specificity:Expressed in spermatids.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
