产品名称
HoxA5 Rabbit Polyclonal Antibody
别名
HOXA5; HOX1C; Homeobox protein Hox-A5; Homeobox protein Hox-1C
蛋白名称
Homeobox protein Hox-A5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3202
Human Swissprot No.
P20719
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20719/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15402
Mouse Swissprot No.
P09021
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09021
Rat Swissprot Link
http://www.uniprot.org/uniprot/P52949
免疫原
Synthesized peptide derived from the N-terminal region of human HoxA5.
特异性
HoxA5 Polyclonal Antibody detects endogenous levels of HoxA5 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expressed during embryogenesis and in adult kidney.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.,similarity:Belongs to the Antp homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
