产品名称
HORMAD1 Rabbit Polyclonal Antibody
别名
HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein
蛋白名称
HORMA domain-containing protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84072
Human Swissprot No.
Q86X24
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86X24/entry
Mouse Swissprot No.
Q9D5T7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D5T7
免疫原
The antiserum was produced against synthesized peptide derived from human HORMAD1. AA range:321-370
特异性
HORMAD1 Polyclonal Antibody detects endogenous levels of HORMAD1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
组织表达
Testis-specific. Over-expressed in carcinomas.
细胞定位
Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). .
功能
similarity:Contains 1 HORMA domain.,tissue specificity:Testis-specific. Over-expressed in carcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
