BD-PT2202

hnRNP K Rabbit Polyclonal Antibody

HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP

常规抗体

HNRNPK

Heterogeneous nuclear ribonucleoprotein K

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3190

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3190

P61978

http://www.uniprot.org/uniprotkb/P61978/entry

15387

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15387

P61979

http://www.uniprot.org/uniprot/P61979

117282

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117282

P61980

http://www.uniprot.org/uniprot/P61980

The antiserum was produced against synthesized peptide derived from human hnRNP K. AA range:250-299

hnRNP K Polyclonal Antibody detects endogenous levels of hnRNP K protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

51kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have

Brain,Cajal-Retzius cell,Colorectal cancer and surrounding

Cytoplasm . Nucleus, nucleoplasm . Cell projection, podosome . Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).

Spliceosome;

function:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA.,mass spectrometry: PubMed:11840567,PTM:Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.,similarity:Contains 1 KH domain.,similarity:Contains 2 KH domains.,similarity:Contains 3 KH domains.,subcellular location:In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.,subunit:Interacts with RBM42 and ZIK1 (By similarity). Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRNPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.