BD-PT2199

hnRNP F Rabbit Polyclonal Antibody

HNRNPF; HNRPF; Heterogeneous nuclear ribonucleoprotein F; hnRNP F; Nucleolin-like protein mcs94-1

常规抗体

HNRNPF

Heterogeneous nuclear ribonucleoprotein F

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3185

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3185

P52597

http://www.uniprot.org/uniprotkb/P52597/entry

98758

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98758

Q9Z2X1

http://www.uniprot.org/uniprot/Q9Z2X1

64200

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64200

Q794E4

http://www.uniprot.org/uniprot/Q794E4

The antiserum was produced against synthesized peptide derived from human hnRNP F. AA range:11-60

hnRNP F Polyclonal Antibody detects endogenous levels of hnRNP F protein.

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

48kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],

Expressed ubiquitously.

Nucleus, nucleoplasm.

function:Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Probably binds G-rich sequences in pre-mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRNPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with TBP and TXNL4/DIM1.,tissue specificity:Expressed ubiquitously.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.