产品名称
HMG-2 Rabbit Polyclonal Antibody
别名
HMGB2; HMG2; High mobility group protein B2; High mobility group protein 2; HMG-2
蛋白名称
High mobility group protein B2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3148
Human Swissprot No.
P26583
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P26583/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=97165
Mouse Swissprot No.
P30681
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30681
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29395
Rat Swissprot Link
http://www.uniprot.org/uniprot/P52925
免疫原
The antiserum was produced against synthesized peptide derived from human HMGB2. AA range:131-180
特异性
HMG-2 Polyclonal Antibody detects endogenous levels of HMG-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008],
组织表达
Expressed in gastric and intestinal tissues (at protein level).
细胞定位
Nucleus . Chromosome . Cytoplasm . Secreted . In basal state predominantly nuclear. .
功能
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
