BD-PT2149

Histone deacetylase 9 Rabbit Polyclonal Antibody

Histone deacetylase 9; HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR

常规抗体

HDAC9

Histone deacetylase 9

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

9734

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9734

Q9UKV0-5,6,7

http://www.uniprot.org/uniprotkb/Q9UKV0-5,6,7/entry

The antiserum was produced against synthesized peptide derived from human HDAC9. AA range:1017-1066

Histone deacetylase 9 Polyclonal Antibody detects endogenous levels of Histone deacetylase 9 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

110kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 9 encoded by HDAC9 has sequence homology to members of the histone deacetylase family. HDAC9 is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).

Nucleus .

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.