BD-PT2139

HisRS Rabbit Polyclonal Antibody

HARS; HRS; Histidine--tRNA ligase; cytoplasmic; Histidyl-tRNA synthetase; HisRS

常规抗体

HARS

Histidine--tRNA ligase cytoplasmic

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3035

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3035

P12081

http://www.uniprot.org/uniprotkb/P12081/entry

15115

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15115

Q61035

http://www.uniprot.org/uniprot/Q61035

The antiserum was produced against synthesized peptide derived from human HARS. AA range:460-509

HisRS Polyclonal Antibody detects endogenous levels of HisRS protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

Brain, heart, liver and kidney.

Cytoplasm .

Aminoacyl-tRNA biosynthesis;

catalytic activity:ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).,similarity:Belongs to the class-II aminoacyl-tRNA synthetase family.,similarity:Contains 1 WHEP-TRS domain.,tissue specificity:Brain, heart, liver and kidney.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.