产品名称
HIPK4 Rabbit Polyclonal Antibody
别名
HIPK4; Homeodomain-interacting protein kinase 4
蛋白名称
Homeodomain-interacting protein kinase 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=147746
Human Swissprot No.
Q8NE63
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NE63/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233020
Mouse Swissprot No.
Q3V016
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3V016
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308449
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4V793
免疫原
The antiserum was produced against synthesized peptide derived from human HIPK4. AA range:511-560
特异性
HIPK4 Polyclonal Antibody detects endogenous levels of HIPK4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
homeodomain interacting protein kinase 4(HIPK4) Homo sapiens This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors .,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
