产品名称
Hint1 Rabbit Polyclonal Antibody
别名
HINT1; HINT; PKCI1; PRKCNH1; Histidine triad nucleotide-binding protein 1; Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1
蛋白名称
Histidine triad nucleotide-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3094
Human Swissprot No.
P49773
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49773/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15254
Mouse Swissprot No.
P70349
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70349
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=690660
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62959
免疫原
The antiserum was produced against synthesized peptide derived from human HINT1. AA range:71-120
特异性
Hint1 Polyclonal Antibody detects endogenous levels of Hint1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015],
细胞定位
Cytoplasm . Nucleus . Interaction with CDK7 leads to a more nuclear localization. .
功能
caution:Was originally thought to be a protein kinase C inhibitor and to bind zinc in solution. Both seem to be incorrect.,domain:The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.,function:Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.,similarity:Belongs to the HINT family.,similarity:Contains 1 HIT domain.,subcellular location:Interaction with CDK7 leads to a more nuclear localization.,subunit:Homodimer. Interacts with CDK7.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
