产品名称
Cleaved-Cathepsin L2 (L114) Rabbit Polyclonal Antibody
别名
CTSL2; CATL2; CTSU; CTSV; Cathepsin L2; Cathepsin U; Cathepsin V
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1515
Human Swissprot No.
O60911
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60911/entry
免疫原
The antiserum was produced against synthesized peptide derived from human CATL2. AA range:95-144
特异性
Cleaved-Cathepsin L2 (L114) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin L2 protein resulting from cleavage adjacent to L114.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011],
组织表达
Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
功能
catalytic activity:The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).,function:Cysteine protease. May have an important role in corneal physiology.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
