产品名称
HBP1 Rabbit Polyclonal Antibody
别名
HBP1; HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1
蛋白名称
HMG box-containing protein 1
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26959
Human Swissprot No.
O60381
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60381/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=73389
Mouse Swissprot No.
Q8R316
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R316
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27080
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62661
免疫原
The antiserum was produced against synthesized peptide derived from human HBP1. AA range:431-480
特异性
HBP1 Polyclonal Antibody detects endogenous levels of HBP1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.,similarity:Contains 1 AXH domain.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.,
组织表达
Brain,Hepatoma,Uterus,
功能
function:Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.,similarity:Contains 1 AXH domain.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
