产品名称
HAT1 Rabbit Polyclonal Antibody
别名
HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1
蛋白名称
Histone acetyltransferase type B catalytic subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8520
Human Swissprot No.
O14929
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14929/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107435
Mouse Swissprot No.
Q8BY71
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BY71
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=296501
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5M939
免疫原
The antiserum was produced against synthesized peptide derived from human HAT. AA range:331-380
特异性
HAT1 Polyclonal Antibody detects endogenous levels of HAT1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009],
组织表达
Brain,Epithelium,Lung,Testis,
细胞定位
[Isoform A]: Nucleus matrix . Mitochondrion .; [Isoform B]: Cytoplasm . Nucleus . Nucleus matrix . Nucleus, nucleoplasm . Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. .
功能
catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:May play a role in telomeric silencing. Acetylates soluble but not nucleosomal H4 at 'Lys-5' and 'Lys-12' and acetylates histone H2A at 'Lys-5'. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.,online information:Histone acetyltransferase entry,similarity:Belongs to the HAT1 family.,subcellular location:Nuclear in S-phase cells and cytoplasmic.,subunit:Heteromer of HAT1 and p46/HAT2 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
