产品名称
Gβ 5 Rabbit Polyclonal Antibody
别名
GNB5; Guanine nucleotide-binding protein subunit beta-5; Gbeta5; Transducin beta chain 5
蛋白名称
Guanine nucleotide-binding protein subunit beta-5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10681
Human Swissprot No.
O14775
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14775/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14697
Mouse Swissprot No.
P62881
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62881
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83579
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62882
免疫原
The antiserum was produced against synthesized peptide derived from human GNB5. AA range:151-200
特异性
Gβ 5 Polyclonal Antibody detects endogenous levels of Gβ 5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008],
信号通路
PI3K/Akt; Insulin Receptor; SAPK_JNK; AMPK
功能
function:Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subunit:G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP.,tissue specificity:Expressed in multiple tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
