产品名称
Gα i-3 Rabbit Polyclonal Antibody
别名
GNAI3; Guanine nucleotide-binding protein G(k) subunit alpha; G(i) alpha-3
蛋白名称
Guanine nucleotide-binding protein G(k) subunit alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2773
Human Swissprot No.
P08754
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08754/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14679
Mouse Swissprot No.
Q9DC51
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DC51
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25643
Rat Swissprot Link
http://www.uniprot.org/uniprot/P08753
免疫原
The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80
特异性
Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],
细胞定位
Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. .
信号通路
Chemokine;Axon guidance;Tight junction;Gap junction;Leukocyte transendothelial migration;Long-term depression;Progesterone-mediated oocyte maturation;Melanogenesis;
功能
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
