产品名称
GSK3α/β Rabbit Polyclonal Antibody
别名
GSK3A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
蛋白名称
Glycogen synthase kinase-3 alpha/beta
反应种属
Human,Mouse,Rat,Drosophila,Drosophila
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2931
Human Swissprot No.
P49840/P49841
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49840/entry
Mouse Gene ID
606496/56637
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=606496
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50686
Rat Swissprot No.
P18265/P18266
Rat Swissprot Link
http://www.uniprot.org/uniprot/P18265
免疫原
The antiserum was produced against synthesized peptide derived from human GSK3 alpha/beta. AA range:246-295
特异性
GSK3α/β Polyclonal Antibody detects endogenous levels of GSK3α/β protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],
组织表达
Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis,
细胞定位
mitochondrion,cytosol,beta-catenin destruction complex,postsynapse,
功能
catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
