产品名称
GSC2 Rabbit Polyclonal Antibody
别名
GSC2; GSCL; Homeobox protein goosecoid-2; GSC-2; Homeobox protein goosecoid-like; GSC-L
蛋白名称
Homeobox protein goosecoid-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2928
Human Swissprot No.
O15499
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15499/entry
Mouse Swissprot No.
P56916
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56916
免疫原
The antiserum was produced against synthesized peptide derived from human GSC2. AA range:131-180
特异性
GSC2 Polyclonal Antibody detects endogenous levels of GSC2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. [provided by RefSeq, Jul 2008],
组织表达
Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably expressed in other tissues at low levels.
功能
developmental stage:Expressed in early human development as well as in a limited number of adult tissues.,disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,function:May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.,similarity:Belongs to the paired homeobox family. Bicoid subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably expressed in other tissues at low levels.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
