产品名称
GRK 7 Rabbit Polyclonal Antibody
别名
GRK7; GPRK7; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
蛋白名称
G protein-coupled receptor kinase 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=131890
Human Swissprot No.
Q8WTQ7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WTQ7/entry
免疫原
The antiserum was produced against synthesized peptide derived from human GRK7. AA range:371-420
特异性
GRK 7 Polyclonal Antibody detects endogenous levels of GRK 7 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008],
组织表达
Retinal cones, outer and inner segments.
细胞定位
Membrane ; Lipid-anchor .
信号通路
Chemokine;Endocytosis;
功能
catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Phosphorylates cone opsins thereby initiating their deactivation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina. Cones and rod.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
