产品名称
GRK 6 Rabbit Polyclonal Antibody
别名
GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6
蛋白名称
G protein-coupled receptor kinase 6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2870
Human Swissprot No.
P43250
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P43250/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26385
Mouse Swissprot No.
O70293
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70293
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97711
免疫原
The antiserum was produced against synthesized peptide derived from human GRK6. AA range:10-59
特异性
GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Membrane; Lipid-anchor.
信号通路
Chemokine;Endocytosis;
功能
catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,PTM:It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
