产品名称
GRK 5 Rabbit Polyclonal Antibody
别名
GRK5; GPRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5
蛋白名称
G protein-coupled receptor kinase 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2869
Human Swissprot No.
P34947
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P34947/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14773
Mouse Swissprot No.
Q8VEB1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VEB1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59075
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62833
免疫原
The antiserum was produced against synthesized peptide derived from human GRK5. AA range:351-400
特异性
GRK 5 Polyclonal Antibody detects endogenous levels of GRK 5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008],
组织表达
Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.
细胞定位
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.
信号通路
Chemokine;Endocytosis;
功能
catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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