产品名称
GRK 3 Rabbit Polyclonal Antibody
别名
ADRBK2; BARK2; GRK3; Beta-adrenergic receptor kinase 2; Beta-ARK-2; G-protein-coupled receptor kinase 3
蛋白名称
Beta-adrenergic receptor kinase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=157
Human Swissprot No.
P35626
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35626/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320129
Mouse Swissprot No.
Q3UYH7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UYH7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25372
Rat Swissprot Link
http://www.uniprot.org/uniprot/P26819
免疫原
The antiserum was produced against synthesized peptide derived from human GRK3. AA range:361-410
特异性
GRK 3 Polyclonal Antibody detects endogenous levels of GRK 3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .
信号通路
Chemokine;Endocytosis;Olfactory transduction;
功能
catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
