产品名称
GRB14 Rabbit Polyclonal Antibody
别名
GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein
蛋白名称
Growth factor receptor-bound protein 14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2888
Human Swissprot No.
Q14449
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14449/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50915
Mouse Swissprot No.
Q9JLM9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JLM9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58844
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88900
免疫原
The antiserum was produced against synthesized peptide derived from human GRB14. AA range:81-130
特异性
GRB14 Polyclonal Antibody detects endogenous levels of GRB14 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
组织表达
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
细胞定位
Cytoplasm . Endosome membrane ; Peripheral membrane protein . Upon insulin stimulation, translocates to the plasma membrane. .
功能
function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to the ankyrin repeat region of TNKS2 via its N-terminus.,tissue specificity:Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
