产品名称
GRASP55 Rabbit Polyclonal Antibody
别名
GORASP2; GOLPH6; Golgi reassembly-stacking protein 2; GRS2; Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59
蛋白名称
Golgi reassembly-stacking protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26003
Human Swissprot No.
Q9H8Y8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H8Y8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70231
Mouse Swissprot No.
Q99JX3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JX3
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9R064
免疫原
The antiserum was produced against synthesized peptide derived from human GORASP2. AA range:181-230
特异性
GRASP55 Polyclonal Antibody detects endogenous levels of GRASP55 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
组织表达
Epithelium,Testis,Uterus,
细胞定位
Golgi apparatus membrane ; Lipid-anchor . Endoplasmic reticulum membrane . Golgi apparatus . Detected in the intermediate Golgi, membrane-associated (By similarity). ER stress triggers its relocalization from Golgi to ER membrane (PubMed:27062250, PubMed:28067262). .
功能
function:May be involved in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane Tgfa.,PTM:Myristoylated. Myristoylation is essential for the Golgi targeting.,PTM:Palmitoylated.,PTM:Phosphorylated in mitotic cells.,similarity:Belongs to the GORASP family.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Forms a RAB2 effector complex with BLZF1/Golgin 45 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Does not interact with GM130.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
