产品名称
Grap Rabbit Polyclonal Antibody
别名
GRAP; GRB2-related adapter protein
蛋白名称
GRB2-related adapter protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10750
Human Swissprot No.
Q13588
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13588/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71520
Mouse Swissprot No.
Q9CX99
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CX99
免疫原
The antiserum was produced against synthesized peptide derived from human GRAP. AA range:1-50
特异性
Grap Polyclonal Antibody detects endogenous levels of Grap protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012],
细胞定位
Membrane ; Peripheral membrane protein . Cell junction, synapse . Localizes at the presynaptic terminal. .
功能
function:Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
